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Transplantation

Mitochondrial

Revolutionizing Regenerative Medicine

What We Are

​The Toronto Mitochondria Transplantation Team is at the forefront of advancing mitochondrial transplantation therapy. Mitochondrial dysfunction is at the heart of numerous diseases, from acute ischemia-reperfusion injuries affecting organs like the heart, liver, lungs, and kidneys, to chronic conditions such as end-stage organ failure and osteoarthritis. These conditions often result from the inability of cells to properly generate and use energy, leading to cellular dysfunction, organ damage, and increased risk of failure. 

Dr. Bodenstein
Dr. Gabriel Siebiger

​Our innovative mitochondrial transplantation therapy directly transfers healthy mitochondria into damaged cells, bypassing the limitations of conventional approaches. This therapy restores cellular energy production, reduces oxidative stress, and improves overall cellular metabolism, which can significantly mitigate or prevent disease progression and organ injury. By integrating cutting-edge mitochondrial biology, AI, bioengineering, and clinical expertise, we are poised to revolutionize how mitochondrial dysfunction is treated and to enhance outcomes for patients facing severe organ injuries and diseases.

Mitochondria and human anatomy

Vision

Our vision is to transform the landscape of regenerative medicine by making mitochondrial transplantation the standard treatment for diseases driven by mitochondrial dysfunction. We strive to empower patients with new hope and possibilities by addressing the fundamental cellular challenges that lead to organ damage and failure, ensuring this revolutionary approach is equitable and accessible for diverse populations worldwide.

Mission

Our mission is to innovate and advance mitochondrial transplantation through a multifaceted approach that integrates cutting-edge bioengineering, AI, and clinical expertise. We aim to optimize mitochondrial isolation, storage, and delivery, ensuring personalized and effective treatments. By partnering with diverse communities, we commit to research that is inclusive and representative, driving improvements in patient care across all demographics.

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